Signaling for Sustained Change: Spotlight on the Potential of TKIs to Deliver Durable Control of Exudative Retinal Disease

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  • Overview

    This activity examines the evolving role of tyrosine kinase inhibitors (TKIs) in treating exudative retinal diseases such as wet age-related macular degeneration (AMD) and diabetic macular edema (DME). Experts discuss limitations of current anti-VEGF therapies, emphasizing challenges with durability and adherence. The series further explores TKI mechanisms and their formulation into sustained-release delivery systems. Detailed overviews of clinical programs (eg, LUGANO, LUCIA, SOL-1, SOL-R) highlight ongoing phase 3 studies evaluating efficacy and treatment intervals. Real-world case discussions further illustrate patient types who may benefit from these investigational agents. The conversation concludes with considerations for integrating TKIs into future practice.

    *Please stay tuned for additional content to this activity available for credit. The maximum amount of credit(s) available for the entire activity is 0.75.

  • Disclosure of Relevant Financial Relationships

    In accordance with the ACCME Standards for Integrity and Independence, it is the policy of Evolve Medical Education, LLC (Evolve) that faculty and other individuals who are in the position to control the content of this activity disclose any real or apparent financial relationships relating to the topics of this educational activity. Evolve Medical Education, LLC (Evolve) has full policies in place that have identified and mitigated financial relationships and conflicts of interest to ensure independence, objectivity, balance, and scientific accuracy prior to this educational activity.   

    The following faculty/staff members have reported financial relationships with ineligible companies within the last 24 months.

    Faculty:
    Roger A. Goldberg, MD, MBA
    Partner
    Bay Area Retina Associates
    Walnut Creek, CA

    Grant Support: AbbVie Inc., AffaMed Therapeutics, Alexion Pharmaceuticals, Inc., Annexon, Inc., Apellis Pharmaceuticals, Inc., Avirmax, Inc., Boehringer Ingelheim Pharmaceuticals, Inc., Carl Zeiss AG, Clearside Biomedical, Inc., Cognition Therapeutics, Inc., Emmetrope Ophthalmics LLC, EyePoint, Inc., Genentech, Inc., Janssen Biotech, Inc., Neurotech Pharmaceuticals, Inc., Novo Nordisk, Inc., Ocular Therapeutix, Inc., Orasis Pharmaceuticals, Regeneron Pharmaceuticals, Inc., Stealth BioTherapeutics, Unity Biotechnology, Inc.
    Consultant Fees: AbbVie Inc., Alimera Sciences, Inc., Annexon, Inc., Apellis Pharmaceuticals, Inc., Boehringer Ingelheim Pharmaceuticals, Inc., Carl Zeiss AG, Clearside Biomedical, Inc., Emmetrope Ophthalmics LLC, EyePoint, Inc., Genentech, Inc., Janssen Biotech, Inc., Neurotech Pharmaceuticals, Inc., Ocular Therapeutix, Inc., Orasis Pharmaceuticals, Regeneron Pharmaceuticals, Inc., Stealth BioTherapeutics, Unity Biotechnology, Inc.
    Speaker Bureau: Apellis Pharmaceuticals, Inc., Genentech, Inc.
    Royalties: Emmetrope Ophthalmics LLC

    Katherine E. Talcott, MD 
    Associate Professor of Ophthalmology
    Cole Eye Institute
    Cleveland Clinic
    Cleveland, OH  

    Consulting Fees: 4D Molecular Therapeutics, Inc., AbbVie Inc., Apellis Pharmaceuticals, Inc., Astellas Pharma Global Development, Inc., Bausch + Lomb Corporation, Carl Zeiss AG, EyePoint, Inc., Genentech, Inc., Harrow Health, Inc., Ocular Therapeutix, Inc., Outlook Therapeutics, Inc., Regeneron Pharmaceuticals, Inc.
    Research: Carl Zeiss AG, Regeneron Pharmaceuticals, Inc

    Christina Y. Weng, MD, MBA
    Fellowship Program Director
    Vitreoretinal Diseases & Surgery
    Houston, TX

    Consulting Fees: AbbVie Inc., Alcon Vision, LLC, Alimera Sciences, Inc., Apellis Pharmaceuticals, Inc., BVI Medical, Inc., Carl Zeiss AG, EyePoint, Inc., Frontera Therapeutics, Inc., Genentech, Inc., Iveric Bio, Inc., Ocular Therapeutix, Inc., Regeneron Pharmaceuticals, Inc., REGENXBIO, Inc., Stealth BioTherapeutics
    Research: DRCR Retina Network
    Royalties: Springer Publishers

    Reviewers/Content Planners/Authors: 

    • Cindy Davidson has no relevant relationships to disclose.
    • Erika Langsfeld, PhD, has no relevant relationships to disclose.
  • Learning Objectives

    Upon completion of this activity, learners should be better able to:

    • Assess the unmet need for durability in treatments for neovascular age-related macular degeneration and diabetic macular edema
    • Explain how the mechanistic basis and drug-delivery platform of tyrosine kinase inhibitors (TKIs) may improve the durability of their therapeutic effect
    • Propose patient and clinical factors that suggest eligibility for TKI therapy
    • Interpret key visual, anatomical, and durability findings from clinical trials assessing TKIs to counsel patients on treatment expectations
  • Target Audience

    This activity has been designed to meet the educational needs of retina specialists and ophthalmologists as well as all other physicians, physician assistants, nurse practitioners, nurses, pharmacists, and healthcare providers involved in managing patients with retinal disease. 

  • Accreditation and Credit Designation Statements

    Evolve Medical Education LLC (Evolve) is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians. 

    Evolve Medical Education designates this enduring activity for a maximum of 0.75 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity. 

  • Provider(s)/Educational Partner(s)

    Evolve Medical Education LLC (Evolve) is a leader in cultivating health care for patients by educating clinical competence of the health care team. Evolve achieves this by developing and distributing high-quality, evidence-based, valid, independent CME/CE activities in a variety of learning formats. These activities are designed to increase clinician’s knowledge, skills, competence and professional performance as well as to promote professional growth, maintenance of licensure, and support quality change in care of patients.

  • Commercial Support

    This activity is supported by an independent educational grant from EyePoint Pharmaceuticals.

  • Disclaimer

    The views and opinions expressed in this educational activity are those of the faculty and do not necessarily represent the views of Evolve. This presentation is not intended to define an exclusive course of patient management; the participant should use his/her clinical judgment, knowledge, experience, and diagnostic skills in applying or adopting for professional use any of the information provided herein. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patients’ conditions and contraindications or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities. Links to other sites may be provided as additional sources of information.

    Reproduction Prohibited 
    Reproduction of this material is not permitted without written permission from the copyright owner. 

  • System Requirements

    • Supported Browsers (2 most recent versions):
      • Google Chrome for Windows, Mac OS, iOS, and Android
      • Apple Safari for Mac OS and iOS
      • Mozilla Firefox for Windows, Mac OS, iOS, and Android
      • Microsoft Edge for Windows
    • Recommended Internet Speed: 5Mbps+

  • Publication Dates

    Release Date:

    Expiration Date: Ongoing Program - Expiration date will be posted when all episodes are published.

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